Posted by med-amorphosis on May 20, 2010, at 7:05:36 [reposted on May 20, 2010, at 18:36:26 | original URL]
In reply to Re: Gone with trimipramine » med-amorphosis, posted by linkadge on May 19, 2010, at 18:19:23
> Think of it this way: Surmontil could have potent dopaminergic effects on account of
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> 1) 5-ht2a/c receptor antagonism
> 2) Muscarinic antagonism
> 3) MAO-B inhibition
> 4) DAT inhibition
> 5) 5-ht2a/c antagonism
> 6) Opioid binding
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> Yes it does have some d2 antagonsm, but this would indirectly shunt more dopamine to d1/d3 etc.
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> Linkadge
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>Thanks. So your saying trimipramine is/could be more (directly/inderectly) dopaminergic than anything else? If so thats interesting as it was his next offer after I highlighted my loss of pleasure in everything, even things I normally love even if I'm down. Fishing is one, but last trip I just wanted to go home allmost strait away. Being around nature is normally theraputic.
med
U.K.resedent
Ills: Avoidant Personality Disorder, major depression, addictive personality
Regime: 90mg isocarboxazid, 4mg clonazepam, 50mg trimipramine-titrating to 100mg
poster:med-amorphosis
thread:948075
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948102.html