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RE: NO, SAMe » Larry Hoover

Posted by tealady on April 30, 2005, at 17:46:11

In reply to Re: fish oil , NO, EPO » tealady, posted by Larry Hoover on April 25, 2005, at 11:08:21

> > "Promotion of nitric oxide induced endothelial relaxation "
> > perhaps its just a side effect of the macrophages producing increased NO while phagocyting along the endothelial linings of the blood vessels ?
> >
> > Just thought that maybe if someone had too much NO already, increased amounts might up the oxidation and peroxynitrates (OK I don't fully understand this) damage too much causes, basically just fishing for a reason why some of us may feel worse of fish oil....maybe those of us who tend to have maybe a fair amount of inflammatory stuff going on..as in autommune disease etc. Just thinking along those lines
> >
> > Jan
>
> It's free unregulated NO that's a problem. As a pressor-modulator (a controller of blood pressure/flow), NO is a good guy. If free NO is a problem, then you need to deal with peroxynitrite stress, as per Dr. Martin Pall.
>
>
I know NO is a good guy . I just thought maybe there is a point where you can have too much? Guess I don't see the diff between free NO and NO. (although I understand free and bound etc)
I remember there is INOs and ENOs(endothelial) too ?
At least I now iknow th worite NO in all caps, grin.

http://molecular.biosciences.wsu.edu/faculty/pall.html
>
> How are you doing, Jan? You're kind of scarce these days.
>
> Lar

Well seeing as you asked and all...

I took a box of SAMe(Natrol SAMe Joint Formula with MSM and glucosamine) and felt good on them.
I'd previously tried MSM and Glucosamine and Chondritin and it had no effect on me , so I assume its was the SANe that was working.

The anxiety went away and I felt calm and relaxed but not depressed..not great as in happy, still sad but not depressed.
It was only 20 tablets and the last 8 or so I gradually spaced ..like every 2nd day then every 3rd day. I took the 2nd last tablet last Monday..and saved one for emergencies..but I took it this morning as I got so depressed yesterday.

It's way worse than before I took them, the anxiety started returning, but the depression outweighed it all. Before I took this last tablet I just wanted to give up.

I can't work it out. I would have thought SAMe levels should just build up in your body..can't see how it can lower anything?
Maybe it's just coincidence ?

Jan



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poster:tealady thread:476058
URL: http://www.dr-bob.org/babble/alter/20050414/msgs/492011.html