Posted by Larry Hoover on May 21, 2005, at 11:39:44
In reply to RE: NO, SAMe » Larry Hoover, posted by tealady on April 30, 2005, at 17:46:11
> I know NO is a good guy . I just thought maybe there is a point where you can have too much? Guess I don't see the diff between free NO and NO. (although I understand free and bound etc)
Rather than too much, think "escaped". NO has a certain physical chemistry. It is highly reactive, something you want from a signalling chemical. It can however, react with other signalling molecules, to form RNS (reactive nitrogen species, analogous to ROS, reactive oxygen species). The high reactivity of RNS causes an organism to develop and maintain specific RNS-reactive molecules (pretty much similar molecules to the antioxidants....some do both) in the vicinity. The signal gets out, but if something bad happens, then the RNS is quenched thereafter. The antioxidants destroy the RNS (destroying the antioxidant too, but it is a sacrificial molecule in the first place).
A moderate release of NO is good. Too little is bad, and too much is bad. Too much usually mean some gets involved with those reactive oxygen species, forming RNS.
If NO diffuses to mitochondria, for example, it can react with superoxide anion to form peroxynitrite, a metastable compound. Metastability means it has a prolonged half-life relative to its reactivity. It's like a mouse trap after it's set. There is a high likelihood of something happening, but if and only if the metastable state is disturbed. A tiny jiggle of the bait in the mousetrap disturbs the metastable state (it could sit that way forever otherwise), and SNAP!, a whole bunch of potential energy is released.
Peroxynitrite goes SNAP!, metaphorically, after being able to travel away from its site of synthesis (defective mitochondria) because of its metastable state. When it "snaps" though, it does major oxidative damage to cell membranes, enzymes, DNA.....whatever happens to be around.
Its when the "fences go down", when RNS escapes its natural boundaries (the antioxidants that would have destroyed it before it got free), that NO's reactivity then becomes a liability (via RNS).
> I remember there is INOs and ENOs(endothelial) too ?
> At least I now iknow th worite NO in all caps, grin.Little letters, usually. iNOS (inducible nitric oxide synthase); eNOS (endothelial nitric oxide synthase); and another, nNOS (neurological nitric oxide synthase). Just to add confusion, the latter two are sometimes considered together as cNOS (constitutive nitric oxide synthase), and the latter one alone is sometimes called bNOS (brain nitric oxide synthase).
I bet there are other confusing acronyms, as well.
However, here is an excellent overview of nitric oxide activity/function etc., at least in so far as it affects respiratory function.
http://www.lumc.nl/1070/research/Algemeen/pdf/784.pdf
> http://molecular.biosciences.wsu.edu/faculty/pall.html
> >
> > How are you doing, Jan? You're kind of scarce these days.
> >
> > Lar
>
> Well seeing as you asked and all...And, please accept my sincere apology for not being around to hear the answer.
> I took a box of SAMe(Natrol SAMe Joint Formula with MSM and glucosamine) and felt good on them.
> I'd previously tried MSM and Glucosamine and Chondritin and it had no effect on me , so I assume its was the SANe that was working.
>
> The anxiety went away and I felt calm and relaxed but not depressed..not great as in happy, still sad but not depressed.I know that exact place. I think it is my "normal".
> It was only 20 tablets and the last 8 or so I gradually spaced ..like every 2nd day then every 3rd day. I took the 2nd last tablet last Monday..and saved one for emergencies..but I took it this morning as I got so depressed yesterday.
Can you/will you get more?
> It's way worse than before I took them, the anxiety started returning, but the depression outweighed it all. Before I took this last tablet I just wanted to give up.I have decided that some of the things I do are like putting in a new well beside one that has gone dry. I might get more water than before I put in the new well, but soon enough, the very same things that caused the old well to go dry also make the new well go dry.
Many of the things I've tried just seem to end up being new ways of using up the old depleted me.
Or....
I just get frustrated and try to do too much and I overwhelm the benefit I was getting, and I seem to "go dry" again.
In any case, I'm better and better, as time goes on. It's a bumpy road I'm on, but I am getting on.
> I can't work it out. I would have thought SAMe levels should just build up in your body..can't see how it can lower anything?
> Maybe it's just coincidence ?
>
> JanSAMe is an intermediate. Whenever you take an intermediate, you run the risk of downregulating something that is sensitive to the concentration of the intermediate. I'm not saying that's what happened. Maybe you exhausted yourself because your improved state of mind did not extend to bodily function? Maybe you body just couldn't keep up? You overdid it, somehow?
I'm sorry it's so hard to be well, Jan. It sucks when you can't depend on a stable degree of health. I know that struggle too well.
The best advice I have is not to fight off the need for rest, when you feel that need come on. That's what really sets me back, when I go on by stubborn effort, rather than from resiliency. I pay for stubbornness 10-fold.
Lar
poster:Larry Hoover
thread:476058
URL: http://www.dr-bob.org/babble/alter/20050510/msgs/500735.html