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Re: fish oil , NO, EPO » Larry Hoover

Posted by tealady on April 10, 2005, at 18:04:52

In reply to Re: fish oil , NO, EPO » tealady, posted by Larry Hoover on April 10, 2005, at 11:23:55

> > I suspect its that fish oil maybe causes a rise in NO
> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8041151&dopt=Abstract
> > and I suspect I have too much already of that(lots of posts on here back in Sept-Nov 2003 I suspect on here when I was having a lot of difficulty with it I suspect or something t do with it anyway)...whereas other people don't have enough...hence the popularity of Viagra :-)
>
> Ah, but this is macrophage NO production. These are white blood "killer" cells, and they use NO to destroy targetted cells/invaders. I don't see this as a generalized increase in NO synthesis. This was entirely a study of macrophage response to prostaglandins/activation.
>
> Lar

I've been seeing this fish oil promotion of NO in many differing places..just forget where
here's another
http://www.oilofpisces.com/cholesterol.html

"Promotion of nitric oxide induced endothelial relaxation "
perhaps its just a side effect of the macrophages producing increased NO while phagocyting along the endothelial linings of the blood vessels ?

Just thought that maybe if someone had too much NO already, increased amounts might up the oxidation and peroxynitrates (OK I don't fully understand this) damage too much causes, basically just fishing for a reason why some of us may feel worse of fish oil....maybe those of us who tend to have maybe a fair amount of inflammatory stuff going on..as in autommune disease etc. Just thinking along those lines

Jan


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