Posted by raybakes on December 3, 2004, at 6:22:44
In reply to Re: dopamine autoreceptor problem » raybakes, posted by KaraS on December 1, 2004, at 22:49:42
> > > Hi Kara,
> >
> > looked up hydrogen peroxide and dopamine and found this abstract that says that H202 can inhibit dopamine release..
> >
> > H(2)O(2) is a novel, endogenous modulator of synaptic dopamine release.
> >
> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11387393&dopt=Abstract
> >
> > Just interested in the H2O2 produced by tyrosine hydroxylase when it lacks it's co factors.
> >
> > ray
> >
>
> Never heard of H2O2 (ROS) before. The abstract says that it's a "modulator" of dopamine release. That doesn't necessarily mean inhibition though, does it?Hi Kara,
H2O2 is hydrogen peroxide - I was concerned that tyrosine hydroxylase could make a potent free radical instead of L DOPA if it didn't have the right nutrients to help it function. cAMP is something that is increased by chocolate and PEA (and hawthorn) and is implicated in the swithching on and off of dopamine metabolism within the cell. Opiates such as morphine (and wheat and dairy opiates) first raise it and then lower cAMP - the lowering of cAMP is thought to cause serotonin and dopamine to fail leading to desire for more opiates. Just had a test from an autism lab - I have unusual tryptophan by-products in my urine that suggest I'm making opiates from wheat and undermining my serotonin metabolism.
There is a possibility that low cAMP could be what brain fog is - not sure as all the info is a bit sketchy!
Ray
poster:raybakes
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/423783.html