Posted by raybakes on December 6, 2004, at 14:01:30
In reply to Re: dopamine autoreceptor problem, posted by linkadge on December 5, 2004, at 11:32:58
> Cofee quickly raises cAMP within the cell.
>
> Coffee has a powerful anti-brainfog effect.
>
> I've had some good sucess with low SSRI doses and coffee.
>
>
Hi the cAMP problem is something that Barry Sears talks about in his "anti-aging zone".What is of interest is that insulin can antagonize cAMP and interleukin 6 can raise insulin!
James South has quite a good article on cAMP..
INSULIN, cAMP, & EFFECTIVE HORMONAL COMMUNICATION
Most hormones deliver their "message" by interacting with specific receptors on outer cell membrane surfaces, although some do penetrate directly into the cell as well. When hormones bind to their appropriate cellular receptors, they normally activate substances inside the cell known as "second messengers" (the hormone [Ed.- hormone is Latin meaning chemical-messenger] is the first "messenger"). These second messengers actually induce the hormonal biological effect inside the cell. Insulin acts through the second messengers inositol triphosphate (IP3) and diacylglycerol (DAG).
Perhaps the commonest second messenger, however, is cyclic AMP (cAMP). "Many hormones do appear to utilize cAMP as a second messenger, including calcitonin, chorionic gonadotrophin, corticotrophin, epinephrine [adrenalin], follicle-stimulating hormone [FSH], glucagon, luteinizing hormone [LH], lipotrophin, melanocyte-stimulating hormone [MSH], norepinephrine [noradrenaline], parathyroid hormone, thyroid-stimulating hormone [TSH], and vasopressin." (9)
Thus, not only are insulin and glucagon opposite in their basic physiologic actions, they were opposing second messengers: IP3/DAG vs. cAMP. Sears points out that "...if a cell has multiple hormone receptors, then the final biological response of the cell depends on which second messenger system (cAMP or IP3/DAG) predominates at that point in time." (7) When hormones such as noradrenaline or glucagon bind to their cell membrane receptors, they activate an enzyme called "adenylate cyclase." This enzyme then produces the cAMP second messenger inside the cell.
Unfortunately insulin opposes cyclic AMP production by adenylate cyclase. (9 Now you can begin to see why Sears considers excessive insulin as the basic pillar of aging. Insulin is one of the few hormones (cortisol being the other major one) which increases with age - most others, such as thyroid, DHEA, testosterone, estrogen, growth hormone, etc. decrease with age.
Now look again at the long list of hormones (and not all of them are listed) which use cAMP as their second messenger, most of which hormones suffer decreased secretion with aging. Since insulin generally increases with age, but opposes cAMP, while most hormones that act through cAMP decrease with age, it is obvious that hyperinsulinemia will tend to distort the overall "symphonic orchestra" of hormone interactions, and thus promote "low fidelity" hormonal communication.
Thus hyperinsulinemia will tend to damage our entire metabolism, because the sum total of the myriad biochemical reactions in our trillions of cells is under the control of our (ideally) tightly synchronized and integrated hormonal "symphonic orchestra." Imagine the sound of a symphony played by an orchestra where one instrument (e.g. the trumpet) is highly amplified while the other instruments are being muted in their sound volume, and you have a crude metaphor for the metabolic dysregulation induced by excessive carbohydrate consumption - caused hyperinsulinemia
poster:raybakes
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/425296.html