Posted by KaraS on December 4, 2004, at 15:28:10
In reply to Re: dopamine autoreceptor problem » KaraS, posted by raybakes on December 4, 2004, at 13:36:29
> > >
> > Thanks for the explanation. It's fascinating that you're able to get that kind of information from the lab. If you're not metabolizing serotonin correctly, wouldn't you be feeling very depressed or does this just refer to the serotonin in the body and not beyond the BBB?
>
> I don't fully understand it, but I do get very depressed if I eat pasta - a little depressed if I eat wheat in small doses. The unusual by-product of serotonin is called IAG and is claimed to be increased by opiates from wheat - other people make opiates from dairy and what's interesting is that opiates have an effect on the presynaptic control of dopamine...I don't claim to understand any of it, but it's interesting that wheat and dairy in some people could disregulate dopmine producing neurons.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9351509
>Ray,
Is there no end to the things that can disrupt dopamine production or transmission? It's overwhelming (and I'm sure we've barely touched on all of the possible factors involved). I must sound like a broken record on this topic but I'm tired of trying to figure it all out. Right now I just want to take a pill and make the problem go away!
> >If you don't mind my asking, how does your autism manifest? I would never think that was an issue of yours from dealing with you on-line. If you don't wish to discuss it that's fine too.
>
> Probably more an aspergers type of person - on a bad day I feel emotionless and want to be alone! The researchers say that people with chronic fatigue and gulf war syndrome often have the same profile.I often want to be left alone. I've always needed a lot more alone time than most people. I guess the difference is that I don't feel emotionless.
> > > There is a possibility that low cAMP could be what brain fog is - not sure as all the info is a bit sketchy!
> >
> > Would be great if they figured out what causes brain fog!
>
> As well as opiates, gaba, glutamate and acetylcholine appear to have an effect on presynaptic dopamine receptors - are they the same as autoreceptors?
>But brain fog can be affected by things that don't in turn effect dopamine receptors, no?
My understanding (and hopefully someone will correct me if I'm wrong) is that if the receptors are presynaptic, then they are autoreceptors.
> Just started reading a book called "prozac backlash" It talks about SSRIs inhibiting dopamine, and so dramatically reducing female hormones. I wonder whether autoimmunity increases with SSRIs, what do you think?There's been some interesting debate about the validity of Glenmullen and Breggin's books on the main board. I'm a bit skeptical of some of their work. The SSRIs inhibiting dopamine is dead on though. Some people seem able to take SSRIs indefinitely without this result for some reason but others of us aren't so lucky. I think that years of SSRI usage may have contributed to my condition now. I strongly suspect that these meds had that negative affect while I was taking them. Now that I am no longer taking them I don't know if they are still a factor in my condition. Unfortunately I can't go back and see if I would still be this anergic had I never taken an SSRI so I will never know for certain how much of a long-term inpact they have had.
I hadn't heard of SSRIs reducing female hormones. That wouldn't surprise me either. I remember that when I would start on an SSRI or go off of one, I would have disruptions in my menstrual cycle. I told my pdoc but she said there's no relationship. I told her I didn't believe that because my body was telling me otherwise and that I thought that in time this would come out. (However, some temporary disruptions in my cycle doesn't necessarily mean that they lowered the hormone levels significantly and over the long-term.)
In terms of autoimmunity, since decreasing hormone levels are associated with more autoimmunity problems, then it does follow logically that SSRIs could impact autoimmunity (if, in fact, the SSRIs do lower hormone levels signficantly). I did develop Hashimoto's while I was on Effexor. Hmmm... Now what was I saying about not buying Glenmullen's theories???? Still, I'd recommend checking out the debate on his work on the main board if you get a chance.
Kara
> Ray
>
>
poster:KaraS
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/424390.html