Posted by SLS on January 1, 2023, at 20:10:48
In reply to Re: Tentative remission on ketamine » SLS, posted by beckett2 on January 1, 2023, at 19:00:42
> > Hi, Beckett2.
> >
> > I was thinking about you and your ketamine treatment earlier today.
> >
> > http://www.dr-bob.org/babble/20220917/msgs/1121438.html
> >
> > Happy New Year!
> >
> > I hope you find something helpful in my hunch.
> >
> >
> > - Scott
>
> Happy New Year to you, too, Scott!
>
> Thank you for the information and support. I hadn't seen that article. While looking and it, I went down a little rabbit hole and found something that addresses our conversation and my own symptoms:
>
> https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02245-5
Great find, Beckett.I don't recall whether or not I discussed with you my being treated with monocycline quite a few years ago. My doctor chose it specifically to see whether or not a substance known to reduce brain inflammation would produce an improvement in my depression. It did. At a time when almost nothing was helping, I experienced a moderate, but consistent improvement for over a year with monocycline. After about 1 1/2 years, I developed black-and-blue marks on the skin of my feet and shins. This is known as hyperpignentation, and is not an uncommon side effect produced by monocycline. It can grow to be very ugly. It is common that the hyperpigmentation appears with a latency of 1-2 years. In most cases, the discolorations on the lower legs disappear, but this can take years. I still had some residual markings after a year. They are gone now. For some people, the hyperpigmentation is irreversible.
It is important to know that no such improvement in depression occurred while I was taking doxycycline - the analog of monocycline in the tetracycline class of antibiotics. I took doxycycline for three months. My doctor wanted to see if doxycyline would produce an improvement as a sort of challenge to assess the possibility that I might have Lyme Disease.
My doctor keeps himself apprised of the latest discoveries coming from the frontier. He has been incorporating brain inflammation into his conceptualizations of the genesis of depression. If you hadn't provided the motivation to look into ketamine, I wouldn't have learned that:
1. The addition of magnesium to ketamine amplifies the inhibition of NMDA receptors and produces a significantly better antidepressant response and reduction in brain inflammation compared to ketamine alone.
2. Magnesium by itself can reduce the rush of calcium ions into the neuron terminals via blocking the calcium channels. This results in a reduction of the release of neurotransmitter. Perhaps magnesium acts as a buffer to prevent an unrestricted influx of calcium ions rushing through the calcium channels that stimulates the release of neurotransmitter from presynaptic storage vesicles into the synaptic cleft, thereupon to bind to receptors located on the postsynaptic membrane.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1121402
URL: http://www.dr-bob.org/babble/20220917/msgs/1121452.html