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Re: Tentative remission on ketamine SLS

Posted by undopaminergic on January 1, 2023, at 10:56:53

In reply to Re: Tentative remission on ketamine beckett2, posted by SLS on January 1, 2023, at 3:18:43

> As an aside, both ketamine and memantine block NMDA receptors. I haven't looked into the variability in the binding affinities of both drugs to the NMDA receptor. Whereas ketamine produces an immediate and robust antidepressant when administered as monotherapy, memantine does not. Clinically, ketamine is clearly a more effective tool to treat depression than memantine is.

You are mostly correct. There can be a lag between memantine initiation and an antidepressant response, but this lag is at most a few days. I would say it doesn't produce remission, but a state similar to (hypo)mania. And the required dose escalates -- I went from 10 mg to about 60 mg/dose. Then I deliberately overdosed with a few *grams*, and that's another story.





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