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Re: Tentative remission on ketamine

Posted by undopaminergic on December 31, 2022, at 14:03:45

In reply to Re: Tentative remission on ketamine, posted by Jay2112 on December 30, 2022, at 15:37:31

> Interesting....there is some new research discussing how the dissociative affects of ketamine, which bring it's therapeutic effects, as well as THC, are those we find in Scizophrenia. I find that too, with mid-dose THC, I get a fairly high dissociative feeling going. Dissociation is not always figured with Scizophrenia, but new studies are showing different:
> I'd take a stab at possible high dopamine levels with something like high GABA levels as well, play a part in this. The serotonin and GABA, along with norepinephrine and dopamine, are said to be increased much by Nardil, in particular, GABA.
> Jay

In my view, NMDA-glutamatergic receptor antagonists, like ketamine or memantine, enhance the *functional* dopaminergic tone, without necessarily elevating dopamine concentrations at all. They achieve stimulant-like or even manic-like effects by a mechanism of action that is distinct from the way stimulants like cocaine or Ritalin do.





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