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Re: Tentative remission on ketamine undopaminergic

Posted by SLS on December 31, 2022, at 17:28:38

In reply to Re: Tentative remission on ketamine, posted by undopaminergic on December 31, 2022, at 14:03:45

Hi, UD.

> In my view, NMDA-glutamatergic receptor antagonists, like ketamine or memantine, enhance the *functional* dopaminergic tone, without necessarily elevating dopamine concentrations at all.

What is "dopaminergic tone"?

How does blocking NMDA receptors result in increased dopaminergic tone?


I am clueless as to what NMDA receptors are all about, other than their endogenous ligand is glutamate.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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