Posted by Jay2112 on December 30, 2022, at 16:54:04
In reply to Re: Tentative remission on ketamine » Jay2112, posted by beckett2 on December 30, 2022, at 15:59:15
> > Interesting....there is some new research discussing how the dissociative affects of ketamine, which bring it's therapeutic effects, as well as THC, are those we find in Scizophrenia. I find that too, with mid-dose THC, I get a fairly high dissociative feeling going. Dissociation is not always figured with Scizophrenia, but new studies are showing different: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964156/
> >
> > I'd take a stab at possible high dopamine levels with something like high GABA levels as well, play a part in this. The serotonin and GABA, along with norepinephrine and dopamine, are said to be increased much by Nardil, in particular, GABA.
> >
> > Jay
>
> I don't know my chemicals very well. So GABA is (perhaps) increased with ketamine?
>Yes, GABA is the main nt affected by ketamine. https://www.karger.com/Article/Fulltext/493425
The NMDA antagonism is part of that, as glutamine is a part of GABA.(GABA works the opposite of glutamine.) I have taken high dose benzo Xanax (5-6mg) and with a wee bit of an SRI, it's like almost heaven! But, it doesn't last long and you just fall asleep. Now, the side effects, in particular disassociation, to me, feel nice, because it takes me "out" of my depression and anxiety. I *love* that feeling. I think I may positively react to ketamine and possibly other psychedelics. Funny that edible cannabis has a similar effect on me, in low doses with CBD and CBG. I am working at trying ketamine through the CAMH here in Canada.
Jay
Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-
poster:Jay2112
thread:1121402
URL: http://www.dr-bob.org/babble/20220917/msgs/1121415.html