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Re: Stims, Cocaine, Nicotine target D4 undopaminergic

Posted by jay2112 on January 27, 2022, at 22:08:13

In reply to Re: Stims, Cocaine, Nicotine target D4, posted by undopaminergic on January 27, 2022, at 8:37:59

> > Just to clarify, stims et al act primarily on the D4 receptor. D4 receptors also are low density in Parkinson's. I personally react very well to stims et al, as do most people. D1-2 agonism agitates me.
> >
> > https://pubmed.ncbi.nlm.nih.gov/24484981/
> >
> > (read the entire article, if you can)
> >
> > Jay
>
> I intend to read the article at some time.
>
> As Linkadge pointed out, the abstract does not suggest psychostimulants act primarily on dopamine D4 receptors. Rather, the article is a review of the role of DA D4-receptors in psychostimulant addiction.
>
> Stimulants are indirect dopamine agonists that do not target any particular receptor directly, but they increase synaptic dopamine, which in turn acts on the full range of DA receptors. If there is a receptor they act "primarily" on, it would be D2 simply because that is the most common DA receptor.
>
> -undopaminergic
>

Well, it's in the wording, but they do (stims) act on D4 in a manner other dopamine agonists don't. My point being, targeting D4 receptors is therapeutic, and if a chemical which only targets D4 were available, it may avoid side effects of the other targets.


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:jay2112 thread:1118321
URL: http://www.dr-bob.org/babble/20211102/msgs/1118353.html