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Re: Stims, Cocaine, Nicotine target D4

Posted by jay2112 on January 28, 2022, at 19:50:34

In reply to Re: Stims, Cocaine, Nicotine target D4, posted by undopaminergic on January 28, 2022, at 8:09:50

> > >
> > > Stimulants are indirect dopamine agonists that do not target any particular receptor directly, but they increase synaptic dopamine, which in turn acts on the full range of DA receptors. If there is a receptor they act "primarily" on, it would be D2 simply because that is the most common DA receptor.
> > >
> > > -undopaminergic
> > >
> >
> > Well, it's in the wording, but they do (stims) act on D4 in a manner other dopamine agonists don't.
> >
> What do you mean by "other dopamine agonists"? For example, according to Wikipedia, pramipexole, a direct dopamine agonist, has some affinity for D4.
> > My point being, targeting D4 receptors is therapeutic, and if a chemical which only targets D4 were available, it may avoid side effects of the other targets.
> >
> It would avoid effects mediated by other dopamine receptors, but that would include all effects and not just adverse effects.
> -undopaminergic

IF you read the entire article, there are selective D4 agonists (i.e. NOT pramipexole) that are EXCLUSIVE to the D4 receptor. They have separate and differentiated effects. What part of that don't you understand?

Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-




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