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Re: Stims, Cocaine, Nicotine target D4

Posted by undopaminergic on January 27, 2022, at 8:37:59

In reply to Stims, Cocaine, Nicotine target D4, posted by jay2112 on January 26, 2022, at 13:06:08

> Just to clarify, stims et al act primarily on the D4 receptor. D4 receptors also are low density in Parkinson's. I personally react very well to stims et al, as do most people. D1-2 agonism agitates me.
> (read the entire article, if you can)
> Jay

I intend to read the article at some time.

As Linkadge pointed out, the abstract does not suggest psychostimulants act primarily on dopamine D4 receptors. Rather, the article is a review of the role of DA D4-receptors in psychostimulant addiction.

Stimulants are indirect dopamine agonists that do not target any particular receptor directly, but they increase synaptic dopamine, which in turn acts on the full range of DA receptors. If there is a receptor they act "primarily" on, it would be D2 simply because that is the most common DA receptor.





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