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Re: Stims, Cocaine, Nicotine target D4

Posted by undopaminergic on January 29, 2022, at 8:05:14

In reply to Re: Stims, Cocaine, Nicotine target D4, posted by jay2112 on January 28, 2022, at 19:50:34

> > > >
> > > > Stimulants are indirect dopamine agonists that do not target any particular receptor directly, but they increase synaptic dopamine, which in turn acts on the full range of DA receptors. If there is a receptor they act "primarily" on, it would be D2 simply because that is the most common DA receptor.
> > > >
> > > > -undopaminergic
> > > >
> > >
> > > Well, it's in the wording, but they do (stims) act on D4 in a manner other dopamine agonists don't.
> > >
> >
> > What do you mean by "other dopamine agonists"? For example, according to Wikipedia, pramipexole, a direct dopamine agonist, has some affinity for D4.
> >
> > > My point being, targeting D4 receptors is therapeutic, and if a chemical which only targets D4 were available, it may avoid side effects of the other targets.
> > >
> >
> > It would avoid effects mediated by other dopamine receptors, but that would include all effects and not just adverse effects.
> >
> > -undopaminergic
> >
>
> IF you read the entire article, there are selective D4 agonists (i.e. NOT pramipexole) that are EXCLUSIVE to the D4 receptor. They have separate and differentiated effects. What part of that don't you understand?
>

I said I *intend* to read it -- I haven't yet. No need to be rude.

> And stims, cocaine, nicotine agonize the D4 receptor much more than most available dopamine agonists...which was the point of the article.
>

If that is indeed a (major) point of the article, I think they would mention it in the abstract.

> There is something exclusive about the D4 receptor that may lead to better treatment for addiction and adhd.
>

Yes, the article proposes that D4 antagonism may be of use in treating stimulant addiction. That would seem to imply that *agonism* is particularly relevant to the *induction* of addiction.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20220128/msgs/1118379.html