Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Stims, Cocaine, Nicotine target D4

Posted by undopaminergic on January 28, 2022, at 8:09:50

In reply to Re: Stims, Cocaine, Nicotine target D4 undopaminergic, posted by jay2112 on January 27, 2022, at 22:08:13

> >
> > Stimulants are indirect dopamine agonists that do not target any particular receptor directly, but they increase synaptic dopamine, which in turn acts on the full range of DA receptors. If there is a receptor they act "primarily" on, it would be D2 simply because that is the most common DA receptor.
> >
> > -undopaminergic
> >
>
> Well, it's in the wording, but they do (stims) act on D4 in a manner other dopamine agonists don't.
>

What do you mean by "other dopamine agonists"? For example, according to Wikipedia, pramipexole, a direct dopamine agonist, has some affinity for D4.

> My point being, targeting D4 receptors is therapeutic, and if a chemical which only targets D4 were available, it may avoid side effects of the other targets.
>

It would avoid effects mediated by other dopamine receptors, but that would include all effects and not just adverse effects.

-undopaminergic


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:undopaminergic thread:1118321
URL: http://www.dr-bob.org/babble/20220128/msgs/1118356.html