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Re: Restarted Abilify - Feeling better. » oceansun

Posted by SLS on October 19, 2014, at 11:58:40

In reply to Re: Restarted Abilify - Feeling better. » SLS, posted by oceansun on October 19, 2014, at 10:17:00

Hi Anita.

Yes, I knew who you were. I know that you have an affinity for the ocean. I was not going to use the name "Anita" unless that was to be okay with you.

Anyway...

> Metformin was no joy. Major GI effects, but maybe I'm just prone to them. No bathroom near my desk at work, so impractical for me :(.

That's too bad. You are not the only one who reacts to metformin that way. My mother has not had a hint of G.I. side effects with metformin.

> Cariprazine sounds interesting. That's one of the drugs you're considering? How do you think D3 action would help you in particular?

D3 receptors are located in the limbic system with greater freqency than D2 receptors whereas D2 predominates in striatal structures. Partial agonism of D3 receptors might be contributory to the antidepressant properties of cariprazine. The reduced binding of D2 receptors by cariprazine should leave it less apt to produce movement and dystonic EPS.

D2 - striatal - movement
D3 - limbic - mood

It really is good to see you again. I never removed you from my contacts list. I'll write soon.

- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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