Posted by phidippus on November 4, 2014, at 13:56:09
In reply to Re: Restarted Abilify - Feeling better. » phidippus, posted by SLS on November 4, 2014, at 7:22:12
>At no time have I tried taking a 5-HT1a partial agonist in the absence of DA partial agonism, so I can't parse the importance of either mechanism.
Have you tried augmenting the 5ht1a agonism with another 5ht1a agonist? Pindolol? Buspar?
Are there any other agents that do DA partial agonism?
> I have not tried Brintellix
What was remarkable about Brintellix was that it started working fairly quickly, most predominately as an anxiolytic, then its antidepressant effects became apparent. I think this may be owed to its 5ht1a full agonism. Unfortunately, Brintellix caused me to cycle and I could not take it anymore.
>nefazodone
What an odd duck. Wouldn't you be worried about liver toxicity?
>Luvox
I can tell you it works wonders for OCD and its been studied in the treatment of psychotic depression (even as monotherapy). Its action on sigma receptors is novel but may owe to its efficacy as an anxiolytic and antidepressant.
>However, at this juncture, I am not inclined to discontinue Parnate in order to try them.
What are you running at? 60%? 40%? I would be very worried about Parnate's efficacy. Its supposed to be your main tool in treating your depression, but it doesn't seem to be all that effective if you're having to augment it with so many other drugs. Its like adding turbo to an engine with faulty fuel injectore in hopes it will help keep the car up to speed. I feel strongly you should be reconsidering the Parnate. Are you afraid switching it out will lead to crushing depression?
>What if they screw up?
What are you afraid will happen? Worsened depression?
>The idea is nice, but the reality is less than impressive for depression.
Don't they adjust the implant while you're awake so you'll know if its working before they close your skull?
>I would first try intranasal ketamine. It is convenient, inexpensive, and effective.
I have spoken with so many people who have tried intranasal ketamine to know its efficacy. It hasn't worked for any of them, so I can't recommend it. IV Ketamine seems to work very well, however. The data just isn't there for intranasal ketamine, where as certain clinics now offer Ketamine infusions and have data to back up its efficacy. For a list of those clinics, check this out: http://www.ketamineadvocacynetwork.org/46-2/ The only drawback is the cost-insurance usually doesn't cover it.
>Optimism?
On a scale of 1 to 10, how would you rate your depression, 1 being the most depressed and 10 being the least depressed?
>I really can't account for it.
I think you found some things to live for. I am also convinced you are not as depressed as you think you are.
What about this neuroscience stuff? You seem to have a knack for it. Why not make a living out of it?
That's what I'm doing ;)Eric
poster:phidippus
thread:1072466
URL: http://www.dr-bob.org/babble/20141017/msgs/1073182.html