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Re: Restarted Abilify - Feeling better. » SLS

Posted by seeking information on October 19, 2014, at 8:25:17

In reply to Restarted Abilify - Feeling better., posted by SLS on October 18, 2014, at 22:13:58

Hi Scott,
I am sorry that you have not felt well. It sounds as though you are getting back onto a treatment plan that will help you.
I noticed you mentioned N-acetylinecysteine. Do you know much about this supplement. I am taking it low dose (600 MGs) concurrently with Prozac, and am concerned that it will interfere with it as from what I understand, it has liver detoxing properties. I found a study where they indicated that apparantly, the mininum effective dose of prozac goes up if one takes NAC with it. It might be trivial have no meaningful impact on a human (they used rats) but I am curious as to whether or not you had ever heard anything about NAC interferring with SSRI use?


> I discontinued Abilify 6 months ago due my to concerns about increased body weight and high triglycerides. I managed to taper and discontinue the drug with minimal discomfort. My depression did not worsen immediately. My guess is that it took about 4 - 6 weeks for me to begin deteriorating. I did not restart Abilify at this time. My doctor and I had already begun to experiment with discontinuing nortriptyline and using desipramine as a substitute once I relapsed. I am back on my previous treatment regime and feeling better. I added back the Abilify a few days ago using a loading dose of 20 mg. I am now taking 10 mg/day.
>
> The whole summer was wasted. Things could be worse, though. At least I was able to recapture an improvement.
>
> I am looking closely at intranasal ketamine. If I manage to get my hands on it, it will take a bit of time to discover the optimal dosage and dosing frequency. If one takes too small a dosage, glutamate (GLU) release is unaffected and of no therapeutic value. The correct intermediate dosage increases GLU release and produces an antidepressant response. However, if one pushes the dosage of ketamine too high, there is a reversal of effect. GLU release is suppressed, and an antidepressant effect fails to emerge. Benzodiazapines can reduce the effectiveness of ketamine. On the other hand, N-acetylinecysteine (NAC) might increase its effectiveness. I would have to look into that more. NAC does modulate GLU function.
>
> After that, vortioxetine (Brintellix), deep rTMS, cariprazine, and even DBS are considerations.
>
>
> - Scott


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poster:seeking information thread:1072466
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