Posted by SLS on October 19, 2014, at 11:36:59
In reply to Re: Restarted Abilify - Feeling better. » SLS, posted by seeking information on October 19, 2014, at 8:25:17
Hi Seeking.
> I noticed you mentioned N-acetylinecysteine. Do you know much about this supplement. I am taking it low dose (600 MGs) concurrently with Prozac, and am concerned that it will interfere with it
I saw your asking this question on another thread. The URL link you provided suggested that whereas the use of N-acetylinecysteine (NAC) requires higher dosages of Prozac, it allows for reduced dosages of the other SSRIs. However, I would not want to make major treatment decisions based upon this study. Afterall, there is quite a bit of interindividual variability in minimum effective dosages without adding NAC. You will just have to discover this minimum effective dosage through clinical titration.
I don't think that the effects of NAC on the liver are consequential on the metabolism of medication. I have not seen a list of cytochrome P450 enzymes that NAC might inhibit or induce. I would have to check on that, though. Actually, Ed_UK would be a better source of information on this. With acetaminophen (paracetamol) poisoning, NAC replenishes the supply of glutathione for detoxification.
I believe that the recommended dosage of NAC in the treatment of mood illness is 2000 mg/day.
NAC reduces extracellular levels of glutamate by inducing its uptake by glial cells (neuron helper cells). It would be my guess that NAC enhances the antidepressant response to lamotrigine (Lamictal). This would perhaps be facilitated by the ability of lamotrigine to reduce synaptic glutamate release.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1072466
URL: http://www.dr-bob.org/babble/20141017/msgs/1072496.html