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Re: Restarted Abilify - Feeling better. » SLS

Posted by oceansun on October 19, 2014, at 10:17:00

In reply to Re: Restarted Abilify - Feeling better. » oceansun, posted by SLS on October 19, 2014, at 7:19:53

Metformin was no joy. Major GI effects, but maybe I'm just prone to them. No bathroom near my desk at work, so impractical for me :(.

Cariprazine sounds interesting. That's one of the drugs you're considering? How do you think D3 action would help you in particular? Hope it comes out soon then!

Lurasidone or Seroquel seem promising if I get too much anxiety. Do you know which one has less risk of EPS? I'm skittish about APs though now since the EPS, even though it's very mild. I like how lurasidone sounds, as it acts opposite to clonidine and clonidine made me almost instantly depressed. And I've always wanted to try Remeron, but the weight gain scared me away.

BTW, this is Anita from the olden days, in case you couldn't tell :). Thank you for the words of hope -- I wish the same for you.


> Hi, Oceansun!
>
> You might want to consider taking metformin to help prevent the emergence of diabetes due to ariprizole (Abilify) treatment.
>
> Also, a drug called cariprazine is nearing FDA approval. It is similar to aripiprazole in that it is a dopamine D2/D3 receptor partial agonist. However, cariprazine displays much greater potency for D3 relative to D2 than does ariprizole. The consequences of this difference in cariprazine mechanisms might include reduced movement EPS, reduced prolactin secretion, reduced weight gain, reduced risk of diabetes, and a more robust antidepressant response. Akathisia is still problematic, but it often occurs as a temporary startup side effect.
>
> Lurasidone (Latuda), another neuroleptic antipsychotic, is supposed to help with depression. However, I have yet to see someone declare it to be magical. It does not act as a DA partial agonist. However, it does act as a serotonin 5-HT7 receptor antagonist, something that it has in common with aripiprazole. You might want to leave aripiprazole in place while you introduce lurasidone. Once you establish a therapeutic dosage of lurasidone, you can then begin to taper the aripiprazole. If you begin to relapse, you can very quickly reinstate your therapeutic dosage of aripiprazole and discontinue the lurasidone. Please note that, unlike aripiprazole, lurasidone is a NE alpha-2 antagonist. It shares this property with mirtazapine (Remeron). Drugs that have this property have historically made me feel worse, and lurasidone was no exception. Of course, this is an atypical reaction. I imagine that more people will be helped than harmed by this pharmacological action.
>
> Keep working! I'm sure that you will be able to optimize your treatment.
>
>
> - Scott


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poster:oceansun thread:1072466
URL: http://www.dr-bob.org/babble/20141017/msgs/1072492.html