Posted by desolationrower on April 4, 2011, at 0:49:55
In reply to Re: Agomelatine and Tranylcypromine for OCD, posted by Dr.Fischer-Terworth on April 3, 2011, at 2:38:20
>
> Hallo,
>
> two years ago I noticed by incident that magnesium (300mg) had some beneficial effects on OCD symptoms. First I guessed this could be
> imagnination but it is in fact the case because 600 mg Magnesium can reduce compulsive urges
> at least to a certain amount.
> Now I recognized that adding Magnesium 600 mg to the regimen Tranylcypromine 40 mg+agomelatine 25 mg, it partially may compensate for
> the (potential) anti-OCD-effects of agomelatine,
> which I attribute to the 5-HT-2c antagonism.
>
> It is known that Magnesium it works for depression and it is supposed to be acting via serotonergic pathways although it seems to be unknown which way.As Mg is also a NMDA-antagonist and the NMDA-antagonist Memantine has been used as an augmenter of SSRI in OCD patients being partial responders to SSRI, it might also act that way. Glutamatergic dysfunction (overactivity
> in the Thalamus) is associated with OCD (shown at least in children and adolescents) and NMDA-antagonism could also facilitate pro-GABA-ergic effects reducing anxiety.
>
> Does anyone have information about magnesiums psychopharmacological profile of action?
>
> Thank you very much for your comments!
>
> Best wishes,ChristianYes, you are right. Like zinc, it can block the calcium flow in NMDA receptors. here is a nice picture http://commons.wikimedia.org/wiki/File:NMDA_receptor.jpg
Most people don't get enough, for mental health as well as regular old body health. blood pressure is another problem from mag deficiency. I notice i get twitchy eye when i don't get enough, like last time i went camping. Improved sleep might affect mental health too, look at this study [1]: most people are mg deficient. when they test depressed people, they have this same sleep pattern. eat your bran, nuts, legumes, cocoa.
-d/r
Effects of a Magnesium Deficient Diet on Sleep Organization in Rats
AbstractThe influence of magnesium, one of the most important cations in the vertebrate body, on the sleep-wakefulness cycle and ECoG patterns in chronically implanted rats recorded during the light period over a 6-hour period was investigated. Two groups of rats were studied. Group 1 (6 rats): after a control period of 2 weeks, the rats were maintained for 9 weeks on a Mg2+-deficient diet. Group 2 (5 rats): after a control period of 2 weeks, the rats were maintained for 7 weeks on a Mg2+-deficient diet followed by 4 weeks on a normal diet (recovery period: weeks 811). Mg2+-deficient diet for 9 weeks induced sleep and ECoG time-dependent alterations. After 67 weeks on a Mg2+-defi-cient diet (n = 11) sleep analysis showed a significant increase of wakefulness (+50%) at the expense of slow wave sleep (24%) but paradoxical sleep was not significantly modified. After 9 weeks of a Mg2+ deficient diet, sleep was desorganized: light sleep and polyspikes occurred indicating an increase in neuronal excitability. When Mg2+ was reintroduced in food and water, sleep organization and ECoG recordings were restored to their original patterns. Our findings which are in line with previous clinical and pharmacological observations provide conclusive arguments for the neuroprotective effect of magnesium ions in neurologic disorders and epileptiform activity. Mg2+ deficiency induces ECoG alterations in the rat which bear some similarities with those seen in neurogenic spasmophilic syndromes in man.
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:980414
URL: http://www.dr-bob.org/babble/20110321/msgs/981906.html