Posted by Dr.Fischer-Terworth on April 3, 2011, at 2:38:20
In reply to Re: Agomelatine and Tranylcypromine for OCD » sk85, posted by Franz on March 27, 2011, at 16:22:16
Hallo,two years ago I noticed by incident that magnesium (300mg) had some beneficial effects on OCD symptoms. First I guessed this could be
imagnination but it is in fact the case because 600 mg Magnesium can reduce compulsive urges
at least to a certain amount.
Now I recognized that adding Magnesium 600 mg to the regimen Tranylcypromine 40 mg+agomelatine 25 mg, it partially may compensate for
the (potential) anti-OCD-effects of agomelatine,
which I attribute to the 5-HT-2c antagonism.It is known that Magnesium it works for depression and it is supposed to be acting via serotonergic pathways although it seems to be unknown which way.As Mg is also a NMDA-antagonist and the NMDA-antagonist Memantine has been used as an augmenter of SSRI in OCD patients being partial responders to SSRI, it might also act that way. Glutamatergic dysfunction (overactivity
in the Thalamus) is associated with OCD (shown at least in children and adolescents) and NMDA-antagonism could also facilitate pro-GABA-ergic effects reducing anxiety.Does anyone have information about magnesiums psychopharmacological profile of action?
Thank you very much for your comments!
Best wishes,Christian
poster:Dr.Fischer-Terworth
thread:980414
URL: http://www.dr-bob.org/babble/20110321/msgs/981806.html