Posted by Franz on March 27, 2011, at 16:22:16
In reply to Re: Agomelatine and Tranylcypromine for OCD, posted by sk85 on March 27, 2011, at 14:45:39
> >Can it be that the 5-HT2c antagonism is not good
> for OCD as negatively affecting serotonergic
> transmission?
>
> I really don't think that's the case or such generalization can be made. Mirtazapine is also 5-HT2C antagonist and works for OCD as proven by studies. I suffer OCD myself and mirtazapine did slightly improve it and didn't make it worse. I'd rather suspect agomelatine's melatonergic effects which could in some way increase dopamine's effect in particular areas of the brain linked to OCD. But that's also very speculative. And sometimes drugs just do that when you start them, i.e. exacerbate symptoms before improving them. Anafranil made my OCD much worse before significantly improving it.
>
> -IkarosHow long did you have to wait for agomelatine´s good effects?. In almost two weeks I am not getting them. Thanks.
poster:Franz
thread:980414
URL: http://www.dr-bob.org/babble/20110321/msgs/981288.html