Posted by Dr. Fischer-Terworth on March 13, 2011, at 5:50:35
Hi,
has anyone an idea about that? I have OCD
(separation anxiety-related, checking and
compulsive reassurance seeking) and I've been responding well to tranylcypromine 40 mg/d for many years. The MAOI helped for minor depressive
symptoms and very well for OCD and anxiety. Because of sleep disorder and mood swings (maybe kind of little hypomanic) agomelatine 25 mg/d was added. With the MAOI on 40 mg the YBOCS-Score
for OCD was about 6 to 8, nearly remission (
10-15 on 30 mg/d).
The agomelatine helped to improve sleep and mood, makes me calm in some way and to enjoy things more that were boring in the "mood crisis".
At the beginning I thought it also helps with
OCD, as 5-HT2c receptor antagonism is also a
feature of some SSRI like Fluoxetine.
But, however, over the months I think that OCD has worsened (YBOCS:15).Can it be that the 5-HT2c antagonism is not good
for OCD as negatively affecting serotonergic
transmission?I'd appreciate to read some answers and idea.
Many thanks,
Christian FT
poster:Dr. Fischer-Terworth
thread:980414
URL: http://www.dr-bob.org/babble/20110220/msgs/980414.html