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Re: SSRI Induced HPTA Disruption

Posted by SLS on February 7, 2009, at 13:31:58

In reply to Re: SSRI Induced HPTA Disruption, posted by linkadge on February 7, 2009, at 13:23:35

> Yes one is a middle aged man on sertraline and mirapex and the other is younger lady on paroxetine CR and mirapex. The man was originally on TCA's but had to change because of a cardiac issue.
> In both cases, the SSRI alone was not controlling depression. Both the man and women stopped the SSRI because the mirapex produced such a rapid improvement. After relapsing, the SSRI was reinitiated and both are (apparently) doing well. They have been doing well for over a year.
> The psychiatrist in my hometown is into using DA agonists for augmentation.
> One study showed that the SSRI fluoextine can prevent tollerance to morphine. I am wondering if the SSRI's can act as anti-tollerance agents towards dopaminergics.
> Linkadge

Hmm. Interesting thought. Perhaps the SSRI is DA sparing (inhibition of release) and prevents a saturation of receptors, so there isn't as much downregulation from DA agonist exposure.

The more I think about it, the more I think you might have something here.

- Scott




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