Posted by linkadge on February 7, 2009, at 13:23:35
In reply to Re: SSRI Induced HPTA Disruption » linkadge, posted by SLS on February 7, 2009, at 8:28:35
Yes one is a middle aged man on sertraline and mirapex and the other is younger lady on paroxetine CR and mirapex. The man was originally on TCA's but had to change because of a cardiac issue.
In both cases, the SSRI alone was not controlling depression. Both the man and women stopped the SSRI because the mirapex produced such a rapid improvement. After relapsing, the SSRI was reinitiated and both are (apparently) doing well. They have been doing well for over a year.
The psychiatrist in my hometown is into using DA agonists for augmentation.
One study showed that the SSRI fluoextine can prevent tollerance to morphine. I am wondering if the SSRI's can act as anti-tollerance agents towards dopaminergics.