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Re: SSRI Induced HPTA Disruption

Posted by bulldog2 on February 6, 2009, at 18:14:22

In reply to Re: SSRI Induced HPTA Disruption bulldog2, posted by SLS on February 6, 2009, at 17:49:39

> > There certainly is also anecdoctal evidence that ssris disrupt sexual function. Probably due to lowering of dopamine which is a key player in hormone production.
> >
> > I read one study where a man on parnate actually had his dopamine and testosterone levels increase.
> >
> > The question is would any of the dopamine agonists given with an ssri maintain dopamine function?
> I would like to know that, too. I hope some people who have tried it chime in. I think the problem with DA receptor agonists is that you get diminishing returns for depression over time. Perhaps this would not be true of sexual dysfunction. Apomorphine, a non-selective DA receptor agonist, almost got approved for erectile dysfunction.
> I would think that Wellbutrin would be the first thing to try in combination with an SSRI to mitigate the reduction in dopaminergic neurotransmission. First and foremost, it does a good job to increase the probability of a robust antidepressant response. Secondly, for some people, it can completely reverse sexual dysfunction.
> - Scott

I remember reading a book about ssris. Don't recall the title. The doc said that Wellbutrin doesn't do a good job reversing sexual problems.

Now the good thing is that he used buspar in conjunction with ssris and that in most cases restored sexual function. I believe that buspar acts as a block on one of the serotonin sites that causes the problem. Maybe I can find the book. But for him buspar and an ssri was the magic combo.




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