Posted by linkadge on April 21, 2006, at 15:03:10
In reply to Re: interesting- re clonazepam and 5-HT transporte, posted by SLS on April 21, 2006, at 14:20:15
I could be wrong, but I think that abstract is confusing since its refering to both presynaptic autoreceptors, and post synaptic 5-ht1a receptors in the forebrain as simply 5-ht1a receptors.
I think that it means that activation of presynaptic autoreceptors inhibits the firing in the ca3 region, and that after ECT these autoreceptors are downregulated and hence fire more in responce to a 5-ht1a autoreceptor antagonist.
(Again, I could be way off!!!)
SSRI's depend on desensitizing autoreceptors to lead to increased sertonergic firing. But, in the case of ECT, manipulation of SERT is unneccessary to reduce autoreceptor activity.
Linkadge
poster:linkadge
thread:629584
URL: http://www.dr-bob.org/babble/20060417/msgs/635578.html