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interesting- re clonazepam and 5-HT transporter

Posted by zeugma on April 20, 2006, at 20:08:27

In reply to Re: Drugs versus Psychotherapy - Backlash?, posted by zeugma on April 20, 2006, at 19:34:02

I found this article on how clonazepam upregulates the serotonin transporter:

Neuropharmacology. 1995 Oct;34(10):1327-33.


Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam.

Lima L, Trejo E, Urbina M.

Laboratorio de Neuroquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela.

Selective central benzodiazepine agonists, such as clonazepam, are known to modify serotonin and 5-hydroxyindoleacetic content in the brain. In order to further study the effect of this benzodiazepine on serotonin turnover rate, rats received clonazepam, 10 mg/kg for 10 days, and the concentrations of serotonin and 5-hydroxyindoleacetic acid were determined in the hippocampus after inhibition of monoamineoxidase with pargyline. The results indicate a reduction in the turnover rate of the monoamine. In addition, the systemic administration of clonazepam produced a decrease in the Bmax of [3H]DPAT binding to 5-HT1A sites in the hippocampus. By contrast, this effect was not observed if clonazepam was delivered into the dorsal raphe nucleus by osmotic minipumps. The binding of [3H]paroxetine to 5-HT reuptake sites was increased by the treatment with clonazepam. The present observations indicate that clonazepam produces a reduction of serotonin turnover rate in the hippocampus of the rat concomitant with a down-regulation of 5-HT1A binding sites, probably by an effect at the forebrain projections. There is also an up-regulation of the serotonin transporter, which might contribute to a reduction in the synaptic availability of serotonin during clonazepam treatment.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8570030&query_hl=98&itool=pubmed_docsum

This might make clonazepam an option similar to tianeptine in its effect on the 5-HT transporter. And it is consonant with the idea that the s/s genotype is prone to anxiety/stress.

-z


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URL: http://www.dr-bob.org/babble/20060417/msgs/635383.html