Posted by tessellated on February 25, 2006, at 12:31:34
In reply to correction, posted by mike99 on February 24, 2006, at 17:41:37
My Pdoc who was a hardcore biochemical guy.
i.e. based his info on research papers, and did often water things down, but was clear.He said provigil blocked presynaptic norephinephrine (NE) autoreceptors.
Autorecptors are molecules located in the presynaptic neuron's axon terminal. It is thought to play a role in providing feedback to the presynaptic neuron and play a role in modulating synaptic activity.
Therefore making the neuron produce more NE, by inhibiting its ability to sense these raised levels of NE.
or
The presynaptic source of norephi (NE) release would be increased due to the autoreceptor not inhibiting the production of more norephinephrine.
Pretty cool no?kinda like tweaking your cars thermostat so it might run hotter.
or altering your computers micro fuse so it would run faster (fun to do on both mac/pc but you can destroy your chip).I think therefore the cardio issues are of concern due to increased levels of NE and the diverse range of effects it has on vasoconstriction and cardio output, respiration, and all sorts of stuff.
I've not personally noticed any BloodPressure and/or cardio effects that are much different than caffeine. Though its got moderate poop out.
But again, the conclusions are not there yet.
Though enough is know to raise concern-untill this concern is proved wrong-which takes research monies.
It's still-relatively a new chemical.Isn't it generic yet? Geesh. Its suppose to be, but is held up in litigation by Cephalon who's gonna market the r-isomer as nuvigil-what b.s.
Modafinil had $289 million, of sales in 2004!Still I would say it is probably the best stim/cognitive enhancing agent to come out for a Loooong time!
poster:tessellated
thread:612884
URL: http://www.dr-bob.org/babble/20060219/msgs/613094.html