Posted by mike99 on February 25, 2006, at 8:55:35
In reply to Re: provigil mechanism of action?, posted by Racer on February 25, 2006, at 3:22:53
Very funnny..."doesn't seem to do anything" =)
Good point.I'm always skeptical when the pharm companies say "we have no idea how it works"---like with the stimulants for example.
Thanks for the info. Novartis and Saegis were/are working on a GABA-B receptor antagonist for ADHD and Alzheimers called SGS-742, but I think they dropped the ADHD trials.
The RxList seems to only claim it doesn't bind to GABA receptors, so I guess that doesn't rule out some sort of GABA reuptake enhancer, if there is such a thing.
There does seem to be a consensus on weak dopamine reuptake inhibition, though that doesn't appear to be the primary mechanism.
poster:mike99
thread:612884
URL: http://www.dr-bob.org/babble/20060219/msgs/613035.html