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provigil mechanism of action?

Posted by mike99 on February 24, 2006, at 17:33:54

Does anyone know provigil's mechanism of action? I've found two contradictory statments on the web:

1. Pharmacologic Action: alpha-1-adrenoceptor antagonist, dopamine reuptake inhibitor (neurotransmitter.net--future list of drugs...)

2. Modafanil does not appear to be a direct or indirect alpha-adrenergic agonist (modafanil.com)

Also: "(modafanil) has minimal effects on cardiovascular and hemodynamic parameters". Is this true? If so why caution in patients with cardiovascular conditions?

Thanks for any feedback.


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poster:mike99 thread:612884
URL: http://www.dr-bob.org/babble/20060219/msgs/612884.html