Posted by Chairman_MAO on May 7, 2005, at 12:00:08
In reply to Nardil,Imipramine » ed_uk, posted by pro_social_soon on May 6, 2005, at 5:40:31
ARe you sure the neurosteroid in question was not allopregNANolone? Pregnenolone is a negative GABA-A modulator, while allopregnanolone is a positive GABA-A modulator, acting at a binding site on the GABA-A receptor distinct from benzodiazepines and barbiturates. Interestingly enough, allopregnaolone builds cross tolerance to diazepam, but not to itself. It is also more potent than benzos. The investigational drug ganaxolone is a methylated synthetic derivative of allopregnanolone that is being studied for epilepsy, but I predict will have profound value in treating PTSD, mood disorders related to the menstrual cycle, as well as SAD, GAD, etc.