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Re: Nardil,Imipramine

Posted by sukarno on May 6, 2005, at 12:16:21

In reply to Nardil,Imipramine » ed_uk, posted by pro_social_soon on May 6, 2005, at 5:40:31

Hi Ed! :-) I sent off an email a few days ago to Uruguay but have not received a reply. I even wrote it in Spanish. Oh well. *sigh* I guess it's gone for good!

" Dr.Liebowitz observed in comparison studies between the TCA "imipramine" (Tofranil) and the MAOI "phenelzine" (Nardil) that while phenelzine was extremely effective in treating Social Anxiety, imipramine showed no efficacy - with the primary difference in the two drugs being the marked pro-DA effect of Nardil. Recent studies also show low levels of sex steroid "pregnenolone sulphate" in those with generalized Social Phobia and GAD (generalized anxiety disorder). Low PS levels are linked with abnormal dopamine function and passivity."

Would this explain low libido in some folks with GAD?

I'm also interested to see if l-deprenyl (selegiline, trade name "Eldepryl" and in Indonesia "Jumex") since it is an MAO-b inhibitor in doses <10mg, could have the same effects as Nardil on panic disorder. I'm assuming it doesn't affect GABA...perhaps it is more like Parnate?

Also, DA agonists tend to lower prolactin levels which can increase libido and motivation.

I wonder if l-deprenyl is a better idea for me than Nardil. I'm afraid also of what dose I should take since all of these drugs are metabolised by CYP2D6.

I highly suspect that I'm a "poor metaboliser".

I've also considered amphetamine but it too is metabolised by 2D6.

The rule of thumb I went by with Prozac and Effexor was to take 1/20 the standard dose and that worked, except I couldn't find an Effexor elixir to take, so I took 1/4 of 25mg dose and it gave me hypertension and severe headache.


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URL: http://www.dr-bob.org/babble/20050504/msgs/494540.html