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Nardil,Imipramine » ed_uk

Posted by pro_social_soon on May 6, 2005, at 5:40:31

In reply to Re: Survector » sukarno, posted by ed_uk on May 6, 2005, at 5:28:39

> Hi Paul!
>
> >Is there some mode of action that Nardil and Tofranil (imipramine) have that is separate from their effects on 5-HT and to a lesser extent NE that causes them to have much higher efficacy than the SSRIs?


Dr.Liebowitz observed in comparison studies between the TCA "imipramine" (Tofranil) and the MAOI "phenelzine" (Nardil) that while phenelzine was extremely effective in treating Social Anxiety, imipramine showed no efficacy - with the primary difference in the two drugs being the marked pro-DA effect of Nardil. Recent studies also show low levels of sex steroid "pregnenolone sulphate" in those with generalized Social Phobia and GAD (generalized anxiety disorder). Low PS levels are linked with abnormal dopamine function and passivity.


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