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and on serotonin

Posted by zeugma on May 29, 2004, at 13:47:58

In reply to Re: TCA-Thorazine resemblances, and more zeugma, posted by Sad Panda on May 29, 2004, at 13:07:02

as I said just now, I need coffee, so I am not going to be long-winded :) But drugs that affect serotonin in a way that increases synaptic availability can cause sleep disruption in people not disposed to this prior to taking the med. Hence the popularity of Remeron, trazodone, small doses of doxepin, etc., to counter SSRI sleep disruption. Well, I have sleep disruption to begin with, and so I think my pdoc is wary of introducing CMI at this point since simply lowering the NOR dose caused a return of these problems. CMI may be a stronger 2a blocker than NOR, but NOR has 2a blockade plus weaker SRI effect, and it is in fact supported by studies that NOR produces much less sleep disruption than CMI. CMI is in fact in a category of its own among TCA's for sleep disruption, although it probably causes less than SSRI's or Effexor.


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poster:zeugma thread:348690
URL: http://www.dr-bob.org/babble/20040527/msgs/351874.html