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Re: wash-out before maoi zeugma

Posted by King Vultan on May 25, 2004, at 14:21:31

In reply to Re: wash-out before maoi King Vultan, posted by zeugma on May 24, 2004, at 13:25:56


>
> What does your book tell you about the receptor blocking affinities of clomipramine? Probably both 5HT-1A and 5HT 2A blockade is therapeutic for me. The great experiment will be to see what 5HT reuptake inhibition does for me, since I have never taken one long enough to determine the nature of its effects. My hope is that the other actions of clomipramine will make the SRI effects tolerable.
> >
>
>

Clomipramine

NE reuptake............+++
5HT reuptake........+++++
DA reuptake..............+
Blockade 5HT1.........+
Blockade 5HT2.......+++
Blockade ACh.........+++
Blockade H1...........+++
Blockade alpha-1....+++
Blockade alpha-2......+
Blockade D2............++

where each + represents a difference of one order of magnitude for Ki, ranging from

+++++ represents Ki = 0.1-1.0
+ represents Ki = 1000-10000


Todd


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poster:King Vultan thread:348690
URL: http://www.dr-bob.org/babble/20040521/msgs/350505.html