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I don't think one can emulate an MAOI

Posted by Chairman_MAO on May 30, 2004, at 22:42:35

In reply to Re: TCA-Thorazine resemblances, and more Sad Panda, posted by zeugma on May 29, 2004, at 13:39:05

In re: "emulating" an MAOI:

Reuptake inhibition and/or enhancement of release, speaking of antidepressants and stimulants, does not produce the same effect as MAO inhibition. MAO-A is present intraneuronally, and so inhibiton thereof produces a rise in the intraneuronal transmitter levels, not just those in the synaptic cleft. Perhaps this has to do with the MAOIs being so robust, or it could be simply that they're just damn potent mood elevators! I am not a neuropsychopharmacologist, so I cannot begin to tell you the relevance this has to anything pertitent to psyhcological health. In fact, I am not sure that human beings possess the epistemic faculties to ever comprehend it! :)

This obviously could be involved in the mechanics of adding TCAs and stimulants to MAOIs.

MAO-B, interestingly enough, is only present outside neurons. I _think_ all of this is correct, at least. There are plenty of people on here with more knowledge on this topic than I have. We need them in THIS discussion! My Effexor-crippled intellect can only muster so much strength tonight.


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