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Re: wash-out before maoi King Vultan

Posted by Sad Panda on May 27, 2004, at 11:46:34

In reply to Re: wash-out before maoi zeugma, posted by King Vultan on May 25, 2004, at 14:21:31

> >
> > What does your book tell you about the receptor blocking affinities of clomipramine? Probably both 5HT-1A and 5HT 2A blockade is therapeutic for me. The great experiment will be to see what 5HT reuptake inhibition does for me, since I have never taken one long enough to determine the nature of its effects. My hope is that the other actions of clomipramine will make the SRI effects tolerable.
> > >
> >
> >
> Clomipramine
> NE reuptake............+++
> 5HT reuptake........+++++
> DA reuptake..............+
> Blockade 5HT1.........+
> Blockade 5HT2.......+++
> Blockade ACh.........+++
> Blockade H1...........+++
> Blockade alpha-1....+++
> Blockade alpha-2......+
> Blockade D2............++
> where each + represents a difference of one order of magnitude for Ki, ranging from
> +++++ represents Ki = 0.1-1.0
> + represents Ki = 1000-10000
> Todd

Hi Todd,

If one + equals a range of 1000-10000, then I would say that + and ++ are would be clinically insignificant. Do you think you could put up some data for the other TCA's? I am fascinated that clomipramine gets a ++ for D2 blockade & I'd also like to see the comparison of the different TCA's that this book offers.





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