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Re: thanks for the info, and another ? zeugma

Posted by King Vultan on May 26, 2004, at 12:42:39

In reply to thanks for the info, and another ? King Vultan, posted by zeugma on May 25, 2004, at 18:46:57


>
> By the way, do you think clomipramine + stimulant comes as close to an MAOI as is possible without actually taking one? My thought is that it might COMBINE the attributes of Parnate and Nardil. (In this comparison I would also include the GABAergic effects of the clonazepam I also take.)
>
>

Well, clomipramine is basically an SSRI with a powerful affinity for serotonin and a relatively low selectivity ratio for 5HT over NE reuptake, meaning that it is also relatively strong as far as increasing norepinephrine transmission. In that respect, I suppose if you added a stimulant, it might come closer to an MAOI than most of the conventional SSRIs, but the same might be said of adding a stimulant to either imipramine or amitriptyline. Both of these blockade NE and 5HT reuptake at roughly the same order of magnitude. You could also make a case for adding a stimulant to Effexor to attempt to simulate an MAOI.

Todd


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poster:King Vultan thread:348690
URL: http://www.dr-bob.org/babble/20040521/msgs/350776.html