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Re: Nardil from Australia = 1950's version.KV King Vultan

Posted by Spotcheck on April 11, 2004, at 13:50:59

In reply to Re: Nardil from Australia = 1950's version.KV Spotcheck, posted by King Vultan on April 11, 2004, at 10:58:01

That's just the problem though Todd. These people do not respond to the new Nardil no matter what dosage level the choose. They can push the dosage as high as 120 mg and still not get enough Phenelzine Sulfate dissolved in the fats of their nervous system to help them at all.

Furthermore, it is quite true that Pfizer began having potency problems with the old Nardil. If you run a search on this problem you will find the exact dates and lots that she had to pull. So what began happening is that people would be dispensed Nardil, but their symptoms would return because the Nardil that they were taking was no longer potent enough to do them any good. In the end, I suspect the decision was made to continue producing Nardil, but to change the excipients from 15 in the old to 9 in the new only 3 of which remained the same. Hence, the new Nardil never was going to be metabolized by as many people due to the number of changes made here. That still might well have been the best Pfizer could do -- if they could not straighten out their manufacturing problem.

They will happily take your complaints, but they cannot do a bloody thing about them, so to complain is virtually worthless.

My recommendation would be then to prescribe either Parnate or Venlafaxine (EffexorRX) since Venlafaxine is the most balanced of the SNRIs out there and is a potent reuptake blocker of BOTH 5HT and NE that has a long half-life. Then, I would recommend people hang on using one of these two medications, and any other adjunct medications that worked well with them, until the FDA finally passes the Selegiline Patch called EMSAM which is manufactured by Somerset Pharmaceuticals that SuzyQ1 mentioned above. That rascal will increase brain concentrations of 5HT, NE and DA -- which is almost exactly what Nardil does, although not quite. Phenelzine Sulfate with the proper excipients or when it is also properly metabolized also increases the brain concentrations Gamma Amino Butyric Acid (GABA) which I have long suspects helps people cope with anxiety disorders.

Todd, I never did mean for you to think that I thought you were insensitive to this issue at all. I just think your explanation about this entire Nardil mess is incorrect as to why Pfizer actually did change Nardil. I think she pretty much had no other choice except to stop producing it entirely.

And of course I have gotten together was a flock of Nardil uses who are having problems with the new Nardil, and we attempt to keep each other going and figure out solutions to this problem in particular. Come visit us at the Anxiety board since this is pretty much all we do talk about.

You can find the link in Strat's post, in fact, if you wish to visit. If you can think of any thing else that can be done though kindly post something about it, will you please?

Thank you very much for replying to this post.

Dave


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