Posted by Spotcheck on April 9, 2004, at 22:49:56
In reply to Re: Nardil from Australia = 1950's version., posted by SuzyQ1 on April 9, 2004, at 18:34:46
We've been on Nardil for almost exactly the same number of years since I first found it for my Psychiatrist in 1978. He was raw one might say. I had to break him in some. It was rough on both of us, but worth it of course.
"For the past few months, I've been on the new formula, and it seems that little by little, it's losing its effectiveness. I thought it was in my mind, til I read all these posts. I've been under some extra stress lately, so I'm not sure if it's psychological, or actually that the drug is not working as well as the earlier version. I take 30 mg. daily (2 pills), and have been fine on that dose for half of the time I've been on Nardil."
That's a low dosage relatively speaking. I now take 45 mg of the new, whereas I only had to take 37.5 mg of the old. I had to kick it up a bit because it's not as effective, which did not please me, although I had no choice.
"For the first 12 years or so, I was on 60 mg. daily. I was able to slowly reduce the dose to 30mg. I'm not sure what's going on, but I sure hope that it's not the new formula, and is just a phase I'm going through. But I'm seriously considering increasing my dose to 45 mg."
If you have to, go ahead and increase the dosage.
There will be an increase in side-effects, but if this is the only medication you take that should no problem at all."for the first time in a long time, as I'm feeling very anxious as well as shaky, even when I try to talk. I wonder if anyone else has had these symptoms?"
Yes, allot of people have, Sue, but so far not me, thank God although it took me two or three trials to get the dosage right, because I take another antidepressant as well. Some people do not respond to it at all, and you well know, that is personally disastrous to them! I've seen careers wrecked over this change in Nardil and people's lives dramatically altered one might say.
"If anyone can get proof that the formula has indeed been changed to make it less effective (even if it's something in the inactive ingredients), then I think that we should file a class action suit against Pfizer. My life could
literally depend on it."I know your life depends upon this medication. Here's the story: of the 15 original excipients in the good "old" Nardil, only 3 remain unchanged and the number of excipients has been reduced to 9 in the "new" Nardil. What Pfizer did is to use the FDA to legally turn Nardil into a generic drug. There is no more "old" Nardil being made in the world to the best of my knowledge, and only Link UK makes another generic version. Link Australia, which will cannot important their Nardil into America uses Link UK's formula, but then actually go to the effort and expense, I might say of adding the old sucrose M and M orange sucrose coating to their Nardil for some reason.
"Also, has anyone heard of the new Selegiline Patch called EMSAM, By Somerset Pharmaceuticals, which is supposed to be approved by the FDA sometime this year?"
I have heard a patch was coming out, but I never knew the manufacturer before. Thank you. That might prove useful indeed.
"It's supposed to work similarly to Nardil, as it increases the levels of serotonin, norepinephrine, and dopamine in the brain, the same as Nardil, but with no food or drug interaction, since it bypasses the stomach."
Yes, but it also increase the concentration of Gamma Amino Butyric Acid (GABA) as Phenelzine Sulfate does? Because if it does not, then I do not see how it can possibly be as effective in treating anxiety disorders as Phenelzine Sulfate is with the proper excipients.. Thank you for this information though, Sue.
poster:Spotcheck
thread:283363
URL: http://www.dr-bob.org/babble/20040407/msgs/334747.html