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Re: Doxepin v Mirtazapine » Sad Panda

Posted by scott-d-o on February 3, 2004, at 16:52:08

In reply to Re: Doxepin v Mirtazapine » scott-d-o, posted by Sad Panda on February 3, 2004, at 5:02:28

>
> It doesn't work like that. 15mg of Mirtazapine saturates all the H1 receptors, having extra doesn't cause more sedation, the excess then starts to go to the other receptors that it is attracted too such as 5-HT2A, alpha-2 adrenic, etc. That's why it has the wierd effect of becoming more stimulating as you increase the dose.
>
> Cheers,
> Panda.
>

where did u get your info that 15mg of mirtazapine occupies 100% of h1 receptors? I do agree that more stimulation would occur as the dose increases with mirtazapine due to alpha-2 antagonism (not a good kind of stimulation at that.) doxepin however is an alpha-1 antagonist so I would expect the opposite adrenergic response to an increased dose, althou it does block reuptake of NE as well which may balance this somewhat.

scott


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URL: http://www.dr-bob.org/babble/20040131/msgs/308976.html