Posted by Sad Panda on February 3, 2004, at 5:02:28
In reply to Re: Doxepin v Mirtazapine » Sad Panda, posted by scott-d-o on February 1, 2004, at 1:31:33
> wow, you must have a lot of time on your hands :-)
>
> keep in mind panda, doxepin is usually prescribed anywhere from 75mg all the way up to a max of 300mg, where as remeron has a *max* dose of 75mg.
>
> according to your data, at the max dose that a pdoc will prescribe, u will get an overall sedative effect that is over 2 times as powerful from the doxepin than the remeron.
>
> so if u have a h1 antagonism fetish, u best go ask your pdoc for doxepin.. ;p
>
> anyhow, thanks for the info..
>
> scott
>It doesn't work like that. 15mg of Mirtazapine saturates all the H1 receptors, having extra doesn't cause more sedation, the excess then starts to go to the other receptors that it is attracted too such as 5-HT2A, alpha-2 adrenic, etc. That's why it has the wierd effect of becoming more stimulating as you increase the dose.
Cheers,
Panda.
poster:Sad Panda
thread:306217
URL: http://www.dr-bob.org/babble/20040131/msgs/308771.html