Posted by scott-d-o on January 29, 2004, at 4:02:57
In reply to Re: doxepin, remeron, whatever.. thread is off-topic » scott-d-o, posted by Sad Panda on January 29, 2004, at 1:09:59
> > Scott, I think if you do some research you will find that Mirtazapine is stronger than Doxepin at blocking H1. 5-HT2a is similar for both while the 5-HT3 abilites of Mirtazapine is great for reversing SSRI & Efexor induced nausea.
>
> >>>how about switching the effexor to the old tricyclic doxepin.. it blocks reuptake of serotonin and norepinephrine, like effexor does
>
> These 2 meds are nearly opposite to each other. Efexor main effect is on Serotonin while Doxepin has practically no effect on Serotonin.
>
> Karen, if you haven't tried either Mirtazapine or Doxepin for sleep then I think they are worth a try.
>
>
> Cheers,
> Panda.
>
>Umn, they are not opposite to each other at all. they both inhibit the reuptake of serotonin and norepinephrine, sounds similar to me. so effexor has a little higher affinity for the serotonin transporter relative to norepinephrine than does doxepin, so what?
I don't kno where u get your info but doxepin was the most powerful antihistamine of the tricyclics and remeron is a second-generation AD that is a very weak antihistamine. here's some abstracts off medline.. note the words *very weak* in the first abstract and *weaker* in the second abstract in regard to mirtazapine's antihistaminic properties..
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Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression.Fawcett J, Barkin RL.
Department of Psychiatry, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612, USA.
Mirtazapine is a presynaptic alpha-2 antagonist that has dual action by increasing noradrenergic and serotonergic neurotransmission. The enhancement of serotonergic neurotransmission is specifically mediated via 5-HT1 receptors because mirtazapine is a postsynaptic serotonergic 5-HT2 and 5-HT3 antagonist. In addition, mirtazapine has only a weak affinity for 5-HT1 receptors and has very weak muscarinic anticholinergic and histamine (H1) antagonist properties.
----------------------------------------------[Antidepressives of the 3rd, 4th and 5th generation]
[Article in Czech]
Svestka J.
Psychiatricka klinika Lekarske fakulty MU, Brno.
Antidepressants are classified into five generations. Preparations of the first generation affect various neurotransmitter systems and are therefore associated with many undesirable effects (e.g. tricyclic antidepressants, maprotiline). The second generation of antidepressants is already devoid of anticholinergic action and their adrenolytic and antihistaminic effects are weaker (e.g. mianserine, mirtazapine, trazodone).
poster:scott-d-o
thread:306217
URL: http://www.dr-bob.org/babble/20040127/msgs/306785.html