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Re: Doxepin v Mirtazapine

Posted by scott-d-o on February 4, 2004, at 19:30:39

In reply to Re: Doxepin v Mirtazapine scott-d-o, posted by Sad Panda on February 4, 2004, at 18:14:40

> > > No Scott, you missed your own point. Anything Doxepin can do, Mirtazapine can do better. Neither drug has any dopamine effects, so why are you talking about Parkinson's & Schizophrenia?? Mirtazapine is a mild anti-depressant that can reverse SSRI induced side-effects & give a good nights sleep, Doxepin is similar, but not as good.
> > >
> > > Cheers,
> > > Panda.
> > >
> > >
> >
> > how can you say they are similar when one is a tricyclic that works by blocking reuptake of serotonin and norepinephrine, and the other works by antagonising postsynaptic serotonin receptors? they are hardly alike at all..
> >
> LOL, You reckoned Efexor & Doxepin where very similiar in a previous post when Doxepin hardly has any effect on Serotonin at all. Doxepin is far closer to Mirtazapine then it will ever be to Efexor.
> Cheers,
> Panda.

umm, huh? yes that's true, doxepin is much more like effexor than mirtazapine.. both block reuptake of serotonin and norepinephrine, I simply said doxepin has a bit higher affinity for the NE transporter, while effexor has a higher affinity for the serotonin transporter.. all the tricyclics do this.. mirtazapine does not block the reuptake of either, therefore it is not similar to either effexor or doxepin. ugh, I'm done w/this thread..




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