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Sam-e; causes 5-HT, NE, DA depletion?

Posted by rod on April 28, 2003, at 5:47:20

So what now? I was thinking it enhanches and raises dopamine, increases 5-HT etc. and is a "miracle drug" for some endogenous depressed.

But have a look at:
"Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism."

...Increased methylation can deplete DA, NE, and 5-HT;..
"S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson's disease-like symptoms."

.. Its biochemical role, which includes the metabolism of dopamine and the synthesis of acetylcholine, also resembles the changes that occur in Parkinson's disease...
"Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa."

..Biochemically, increased methylation can cause the depletion of DA, NE, 5-HT...

Is this really well known, and just I didnt know of this? Isnt Sam-e known to induce mania? but how? Did I miss something? I dont understand this!

I dont know any further





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