Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Sam-e; causes 5-HT, NE, DA depletion?

Posted by Larry Hoover on April 28, 2003, at 10:01:15

In reply to Sam-e; causes 5-HT, NE, DA depletion?, posted by rod on April 28, 2003, at 5:47:20

> So what now? I was thinking it enhanches and raises dopamine, increases 5-HT etc. and is a "miracle drug" for some endogenous depressed.
> But have a look at:
> "Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism."
> ...Increased methylation can deplete DA, NE, and 5-HT;..
> "S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson's disease-like symptoms."
> .. Its biochemical role, which includes the metabolism of dopamine and the synthesis of acetylcholine, also resembles the changes that occur in Parkinson's disease...
> "Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa."
> ..Biochemically, increased methylation can cause the depletion of DA, NE, 5-HT...
> Is this really well known, and just I didnt know of this? Isnt Sam-e known to induce mania? but how? Did I miss something? I dont understand this!
> I dont know any further
> bye
> Roland

Infusing a substance into the vesicles of the brain is a most unnatural event. Drawing any conclusions from such a gross manipulation is ill advised.

Think empirically. What happens when people use SAMe? Invoking rational explanations which may or may not have any validity does nothing to change whether or not SAMe works as an antidepressant.

One problem I have with SAMe as an intervention is that it bypasses all the biochemical feedback mechanisms that would normally regulate its concentration in specific tissues. I'm much more comfortable with TMG (betaine), because it enhances SAMe by recycling homocysteine to methionine. The enzymatic reaction that forms SAMe from methionine will remain in regulation by product-dependent feedback mechanisms. You won't get too much in the wrong places (like the ventricles).





Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Larry Hoover thread:222842